Get Your Kicks on Route 66 Welcome to our fully renovated hotel & conference center, completed in 2023! Full-service, free parking & pet friendly! Our property features room to spread out in a vibrant lobby with spaces to gather, relax & work. The all new courtyard boasts a heated pool, cabanas & fireplaces with cozy seating & plenty of natural light to feel refreshed! Enjoy yard games under the string lights on the patio or workout in our new fitness center overlooking it all! Located on historic Route 66 at highway I-44 & I-270, just 14 miles from the Gateway Arch! We are centrally located to everything St. Louis has to offer & are minutes from top attractions: experience a St. Louis CITY SC game at CITYPARK, visit the St. Louis Zoo, Science Center, Missouri Botanical Gardens, Magic House, Six Flags or World Wide Technology Soccer Park. The hotel is just a short drive to Webster University, Harris-Stowe, St. Louis University & Washington University. Just a few miles to top medical centers, Barnes Jewish Hospital, St. Louis Children´s Hospital, SSM, & Mercy Hospitals. Welcoming all travelers to our 213-room hotel & 15,000 sf of space for your next event. Sunset Event Space, operated by Twisted Tree, is the perfect spot to book your wedding or special event. Start your day at Wakey Wakey & then enjoy lunch or dinner at Award-winning Twisted Tree Steakhouse adjacent to the hotel. .

Have a good time at the Holiday Inn St. Louis SW-Route 66. Relax in nice weather on a lounger by the outdoor pool or have a rest in your comfortable room. Later on, you can try some typical American food in the restaurant.

Up to 2 children under the age of 18 stay for free when sharing their parents´ room. Children under the age of 13 are offered breakfast and meals from the children´s menu free of charge when eating together with their family.