The hotel is located in the south of Indianapolis, Indiana. It is about a 15-minute drive via Interstate 65 to both the popular centre and the prosperous business district. This makes the location of the hotel equally attractive for both private and business travellers.

The Hampton Inn Indianapolis-South hotel is located on the south side of Indianapolis, Indiana, just three miles north of Greenwood and eight miles south of downtown Indianapolis. Area attractions near the Hampton Inn South Indianapolis include Greenwood Park Mall, one of the city's largest malls, golf courses, museums, basketball, boating, fishing, the Indianapolis Zoo and Indianapolis University. The Indianapolis Speedway is 22 miles west of the hotel. Guests can dine at nearby restaurants that include Bob Evans, Cracker Barrel, Texas Roadhouse, Wendy's, Cheeseburger In Paradise, Carrabas and Bobbie Jo's Beef and Brew. The Indianapolis Hampton Inn-South features interior hotel room entrances, non-smoking facility. The 112 amenity filled hotel rooms include coffeemaker, hair dryer, iron and ironing board, complimentary high-speed internet access and cable TV with movie channel. Indiana guests can request connecting rooms, cribs and valet laundry services. New Deluxe rooms available King w/sofa bed or Two Doubles, either come with Refrigerators & Mirowaves, 32'' Flat Panel TVs, deluxe adjoining rooms based on availability Sure to please the busy executive or leisure Indiana traveler, Indianapolis, hotel guests will enjoy complimentary On the House hot breakfast buffet served daily. And after a busy day, guests can relax in the hotel indoor swimming pool or work out in the fitness center. Meeting and banquet facilities that accommodate up to 25 people are available for a nominal fee. We love having you here in Indiana at the Hampton Inn Indianapolis-South hotel!