The vicinity to the baseball stadium Progressive Field makes this hotel an ideal retreat for business and private travellers in the city centre. The Cleveland Convention Center is accessible within a few minutes by car and the nearby interstates connect the hotel with Cleveland Hopkins International Airport.

The Hilton Garden Inn Cleveland Downtown hotel is located across from Progressive Field (formerly Jacob's Field and home of the Cleveland Indians) and two blocks from Quicken Loans Arena (the Q) and CSU Wolstein Center. The hotel is conveniently located for easy access and within walking distance to many Downtown Cleveland attractions. These include: Rock and Roll Hall of Fame and Museum, First Energy Stadium, Great Lakes Science Center with OMNIMAX Theater, Playhouse Square Theater District (State, Ohio, Allen and Hanna Theaters), House of Blues Cleveland and East 4th Entertainment District, Cleveland Convention Center, Tower City Mall. The hotel is just a short drive from: Cleveland Clinic, University Hospital, Cleveland Art Museum, Case Western Reserve University & University Circle, Cleveland Botanical Garden, Cleveland Museum of Natural History, Severance Hall-Home of the Cleveland Orchestra, Time Warner Cable Amphitheater (delete), Jacobs Pavilion at Nautica , The Cleveland Hopkins International Airport, Cleveland Metroparks Zoo and the Rainforest.